An exciting new study published in the prestigious journal Nature shows for the first time that manipulation of a brain chemical in a single region influences lifespan.
The authors conclude:
“To summarize, our study using several mouse models demonstrates that the hypothalamus is important for systemic ageing and lifespan control. This hypothalamic role is significantly mediated by IKK-band NF-kB-directed hypothalamic innate immunity involving microglia–neuron crosstalk. The underlying basis includes integration between immunity and neuroendocrine of the hypothalamus, and immune inhibition and GnRH restoration in the hypothalamus or the brain represent two potential strategies for combating ageing-related health problems.”
See on extremelongevity.net